HMG
PH-HMG-001
Specifications
Description
HMG (Human Menopausal Gonadotropin) contains equal amounts of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) derived from the urine of postmenopausal women. This gonadotropin preparation is established for stimulating ovarian and testicular function in fertility treatment.
Mechanism of Action
HMG provides exogenous FSH and LH to stimulate gonadal function. FSH promotes follicular development and spermatogenesis, while LH triggers ovulation and supports Leydig cell testosterone production. No detrimental effect of the LH activity of HMG on clinical outcomes has been observed in IVF; in fact, beneficial effects on fertilization rates were demonstrated compared to pure FSH (Westergaard et al., 1996). Combined FSH/LH activity supports complete reproductive axis stimulation (Gordon & Sauer, 1995).
Research Applications
- Fertility and assisted reproduction research (Westergaard et al., 1996)
- Hypogonadotropic hypogonadism studies
- Spermatogenesis stimulation
- Ovulation induction research
- HPG axis restoration
Product Specifications
- Composition: FSH and LH (1:1 ratio)
- Activity: 75 IU FSH + 75 IU LH per vial
- Form: Lyophilized powder
- Storage: 2-8°C
References
- Westergaard LG, et al. "The effect of human menopausal gonadotrophin and highly purified, urine-derived follicle stimulating hormone on the outcome of in-vitro fertilization." Hum Reprod. 1996. PMID: 8671425
- Gordon CM, Sauer MV. "Generic human menopausal gonadotropin (hMG) in place of more costly follicle-stimulating hormone (FSH) for routine ovulation induction." Fertil Steril. 2001. PMID: 11155320
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
HMG is a synthetic peptide compound used in laboratory research settings. Researchers studying peptide biology use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for HMG — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines