KPV Peptide
PH-KPV-001
Specifications
Description
KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal sequence of alpha-melanocyte stimulating hormone (α-MSH). This anti-inflammatory peptide inhibits NF-κB activation without melanocortin receptor binding.
Mechanism of Action
KPV exhibits potent anti-inflammatory effects in murine models of inflammatory bowel disease (Kannengiesser et al., 2008). Research shows efficacy as a mucoadhesive hydrogel for oral mucositis treatment (Shao et al., 2021).
Research Applications
- Inflammatory bowel disease (Kannengiesser et al., 2008)
- Oral mucositis treatment (Shao et al., 2021)
- Anti-inflammatory mechanism studies
- Cytokine modulation research
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 342.43 Da
- Sequence: Lys-Pro-Val
- Form: Lyophilized powder
- Storage: -20°C
References
- Kannengiesser K, et al. Peptides. 2008. PMID: 18092346
- Shao W, et al. Drug Deliv. 2021. PMID: 34846053
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
KPV Peptide is a synthetic peptide compound used in laboratory research settings. Researchers studying antimicrobial peptide activity use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for KPV Peptide — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
