The research peptide market went through the biggest shakeout it has ever seen across 2025 and 2026. A long list of vendors, including the largest names in the space, shut down in under a year. This is a running list of who closed, what we know about each, and the pressure that drove the wave. We will update it as the picture changes.
The vendors that shut down
- Peptide Sciences. The largest and most established research peptide vendor, based in Henderson, Nevada. It shut down permanently on March 6, 2026, with no announced refund process, leaving a large base of customers stranded. It had reported roughly $7.4 million in online sales in December 2025 alone.
- Science.bio. Closed permanently on January 27, 2026. Unlike most of the others, it wound down responsibly and committed to fulfilling or refunding outstanding orders before it shut the doors.
- Amino Asylum. Forced offline in June 2025 after FDA agents raided its warehouse. This was the first physical raid of a major vendor and it put the whole market on notice.
- Paradigm Peptides, Royal Research, and others. Part of the same wave. At least eight major vendors closed or went dark between the middle of 2025 and early 2026.
Why it happened
No single cause. Several forces converged on the same business model at the same time.
- FDA enforcement. Warning letters went out to multiple peptide sellers in December 2024, and more than fifty letters went to GLP related compounders and manufacturers in September 2025. The June 2025 raid on Amino Asylum raised the stakes from letters to physical action.
- Pharmaceutical litigation. Eli Lilly filed a trade complaint in March 2024 over imported tirzepatide, and a January 2025 trade ruling blocked infringing tirzepatide imports broadly.
- Criminal cases. The Department of Justice secured guilty pleas tied to illegal peptide distribution in late 2025, moving the pressure from civil to criminal.
- New legislation. Federal legislation was introduced in early 2026 to explicitly ban selling research chemicals that are biologically identical to approved drugs.
- Payment processors. Many began treating peptide sales as high risk and cutting vendors off, which choked the operations that survived everything else.
Where researchers source now
The closures left a lot of researchers asking the same question. Where do I buy now, and how do I avoid a vendor that disappears with my money.
Peptide Hackers carries the compounds these vendors were known for, with a per batch Certificate of Analysis, HPLC verified purity, and mass spectrometry confirmation on every order. It also runs two physical storefronts in Los Angeles and Newport Beach, so you can pick up the same day in person and pay at the counter rather than prepaying a website that might not be there next week.
For the deeper story, see our Peptide Sciences shutdown breakdown, the Science.bio alternative guide, and the catalog guide to where each compound is sourced now.
All products are for laboratory research only. Not for human or veterinary use.
Research Use Only
This article is provided for educational purposes. All peptides discussed are sold for research use only and are not intended for human consumption or therapeutic use.