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Metabolic Research Peptides

Peptides examined in metabolic pathway studies, receptor binding experiments, and energy balance research applications.

5-Amino-1MQ research peptide vial
≥99%PH-5A1MQ-001

5-Amino-1MQ

$81.00
MW188.2 Da
GradeResearch

5-Amino-1MQ is a high-purity (≥99%) small molecule NNMT inhibitor with a molecular weight of 188.2 Da. This research compound is studied for its role in nicotinamide N-methyltransferase pathway modulation and metabolic research applications. Supplied as a lyophilized powder, store at -20°C desiccated and protected from light. Ideal for in-vitro studies examining cellular metabolism, NAD+ salvage pathways, and energy homeostasis.

AICAR research peptide vial
≥99%PH-AICAR-001

AICAR

$80.00
MW258.2 Da
GradeResearch

AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a high-purity (≥99%) AMPK activator with a molecular weight of 258.2 Da and molecular formula C9H14N4O5. This adenosine analog serves as a valuable tool for metabolic pathway research and cellular energy sensing studies. Supplied as a crystalline powder, store at -20°C desiccated. Widely used in studies examining glucose uptake, fatty acid oxidation, and metabolic regulation.

Retatrutide research peptide vial
99.579%PH-RETA-001

Retatrutide

$110.00
MW~4700 Da
GradeResearch

Retatrutide (LY3437943) is a novel triple-agonist peptide developed by Eli Lilly that simultaneously targets glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. This multi-receptor approach distinguishes it from single-agonist compounds like semaglutide (GLP-1 only) and dual-agonists like tirzepatide (GIP/GLP-1). **Mechanism of Action** The compound's triple-receptor mechanism produces complementary effects: GLP-1 receptor activation slows gastric emptying and enhances satiety signaling; GIP receptor activation appears to improve insulin sensitivity and lipid metabolism; glucagon receptor activation increases hepatic glucose production acutely while enhancing energy expenditure through thermogenesis and promoting hepatic lipid oxidation (Finan et al., 2015). **Clinical Research** Phase 2 clinical data published in The New England Journal of Medicine demonstrated dose-dependent effects across multiple metabolic parameters at doses ranging from 1mg to 12mg weekly over 48 weeks in 338 participants. The study observed improvements in glycemic parameters, triglyceride levels, and blood pressure measurements (Jastreboff et al., 2023). Phase 3 trials are currently evaluating retatrutide across multiple indications. **Pharmacokinetics** Retatrutide demonstrates a half-life of approximately 6 days, enabling once-weekly subcutaneous administration. Steady-state plasma concentrations are typically achieved by weeks 4-5 of repeated dosing. The extended half-life results from structural modifications including fatty acid acylation, similar to other long-acting incretin analogs. **Safety Profile** Clinical trial data indicates gastrointestinal effects (nausea, diarrhea, vomiting) as the most commonly reported adverse events, consistent with the incretin class mechanism. Dose escalation protocols are typically employed to improve tolerability (Rosenstock et al., 2023). **Research Applications** Retatrutide is of significant interest to researchers studying multi-receptor pharmacology, metabolic pathway interactions, energy homeostasis, and adipose tissue physiology. The compound remains investigational and has not received regulatory approval. **References** 1. Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526. 2. Rosenstock J, et al. Lancet. 2023;402(10401):529-544. 3. Finan B, et al. Nat Med. 2015;21(1):27-36. This product is supplied exclusively for in vitro research and laboratory investigation. Not intended for human or animal use.

Semaglutide research peptide vial
99.982%PH-SEMA-001

Semaglutide

$75.00
MW4113.6 Da
GradeResearch

Semaglutide is a GLP-1 receptor agonist peptide widely used in metabolic and endocrine research. This 31-amino acid peptide features modifications that extend its research utility, including an acylated lysine residue for enhanced stability. Key specifications: • Purity: 99% (HPLC verified) • Molecular Weight: 4113.6 Da • Form: Lyophilized powder • Storage: -20°C, protected from light Research applications include glucose-dependent insulin secretion studies, appetite regulation mechanisms, and comparative pharmacology with other incretin mimetics. Semaglutide's prolonged activity profile makes it valuable for extended observation protocols. Third-party tested with Certificate of Analysis.

Tirzepatide research peptide vial
99.505%PH-TIRZ-001

Tirzepatide

$110.00
MW4813.5 Da
GradeResearch

Tirzepatide is a dual GIP/GLP-1 receptor agonist peptide used extensively in metabolic and endocrine research. This 39-amino acid synthetic peptide represents a significant advancement in incretin-based research compounds. Key specifications: • Purity: 99% (HPLC verified) • Molecular Weight: 4813.5 Da • Form: Lyophilized powder • Storage: -20°C, protected from light The dual-agonist mechanism allows researchers to study synergistic effects of GIP and GLP-1 receptor activation on glucose metabolism, insulin secretion, and appetite signaling pathways. Tirzepatide has become essential for comparative studies in metabolic research. Includes Certificate of Analysis.

Research Use Notice

All products in this category are supplied exclusively for laboratory research purposes. These materials are not intended for human or veterinary use, diagnostic procedures, or clinical applications.