Catalog no. PH-CAGRI-001Size 10mg
Description
CagriSema is a lyophilized research blend combining cagrilintide and semaglutide, two peptides targeting amylin and GLP-1 receptors. This product is supplied with a purity of 99% or higher and is intended for metabolic research applications including studies on appetite regulation, glycemic control, and combined receptor pharmacology. Store at -20°C protected from light.
Mechanism of Action
CagriSema combines cagrilintide (long-acting amylin-receptor agonist) with semaglutide (GLP-1 receptor agonist), studied as a genuinely co-administered combination. REDEFINE 2 (n=1206, phase 3a RCT) found -13.7% mean body-weight change vs -3.4% placebo at 68 weeks in adults with obesity and type 2 diabetes (Davies et al., 2025).
Research Applications
- Co-administered amylin/GLP-1 receptor agonism, phase 3 RCT (PMID: 40544432)
- Weight-management and glycemic outcomes in type 2 diabetes (PMID: 40544432)
- Secondary synthesis of cagrilintide/CagriSema efficacy vs. semaglutide monotherapy, systematic review (PMID: 41834765)
References
- Davies MJ, et al. Cagrilintide-Semaglutide in Adults with Overweight/Obesity and Type 2 Diabetes (REDEFINE 2). N Engl J Med. 2025. PMID: 40544432
- Efficacy and Safety of Cagrilintide and CagriSema Versus Semaglutide — systematic review/meta-analysis. PMID: 41834765
SpecsCompound Specifications
Compound Specifications
- Form
- Lyophilized powder
- Storage
- −20°C or below, protected from light and moisture
HandlingStorage & Handling
Storage & Handling
Storage
CagriSema is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
ResearchResearch Overview
Research Overview
CagriSema is a synthetic peptide compound used in laboratory research settings. Researchers studying metabolic regulation and energy homeostasis use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Certificate publication for this lot is in progress.
CagriSema compound facts
- Key PubMed references
- PMID 40544432, PMID 41834765
Research articles on CagriSema
Documentation & Resources
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What is CagriSema?
CagriSema is a research compound supplied for in-vitro laboratory use. Supplied for metabolic research laboratory research. Research Use Only — not for human or veterinary use.
What purity is CagriSema?
Certificate publication with an HPLC purity figure is in progress for CagriSema.
Does CagriSema include a Certificate of Analysis?
Certificate publication for CagriSema is in progress.
How should CagriSema be stored?
CagriSema is supplied as a lyophilized powder. Store it at −20°C or below, protected from light and moisture — lyophilized material is stable frozen. Once reconstituted, keep it refrigerated and avoid freeze-thaw cycles.
How is CagriSema shipped?
Orders ship at a $15 flat rate, free on orders of $200 or more, in discreet, insulated packaging. Domestic delivery takes 2–3 business days — 2-day across California, nearby Nevada, and on orders of $250+.
Can CagriSema be used on humans or animals?
No. CagriSema is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
