AICAR
PH-AICAR-001
Specifications
Description
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is an AMP-activated protein kinase (AMPK) activator that mimics the metabolic effects of exercise. This nucleoside analog has been extensively studied as an exercise mimetic.
Mechanism of Action
AICAR is phosphorylated to ZMP (AICA ribotide), which activates AMPK by mimicking AMP binding. AMPK activation enhances glucose uptake, fatty acid oxidation, and mitochondrial biogenesis (Višnjić et al., 2021). Research shows AICAR prevents diabetic neuropathy through mitophagy regulation (PMID: 39795939).
Research Applications
- AMPK signaling pathway studies (Višnjić et al., 2021)
- Exercise mimetic research
- Metabolic syndrome models
- Diabetic neuropathy studies (PMID: 39795939)
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 258.23 Da
- Form: White crystalline powder
- Storage: -20°C
References
- Višnjić D, et al. Int J Mol Sci. 2021. PMID: 34064363
- AICAR diabetic neuropathy study. 2024. PMID: 39795939
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
AICAR is a synthetic peptide compound used in laboratory research settings. Researchers studying metabolic regulation and energy homeostasis use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for AICAR — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
