AICAR
Catalog no. PH-AICAR-001Size 10mgMW (reference) 258.23 DaSequence C9H14N4O5
Description
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is an AMP-activated protein kinase (AMPK) activator that mimics the metabolic effects of exercise. This nucleoside analog has been extensively studied as an exercise mimetic.
Mechanism of Action
AICAR is phosphorylated to ZMP (AICA ribotide), which activates AMPK by mimicking AMP binding. AMPK activation enhances glucose uptake, fatty acid oxidation, and mitochondrial biogenesis (Višnjić et al., 2021). Research shows AICAR prevents diabetic neuropathy through mitophagy regulation (PMID: 39795939).
Research Applications
- AMPK signaling pathway studies (Višnjić et al., 2021)
- Exercise mimetic research
- Metabolic syndrome models
- Diabetic neuropathy studies (PMID: 39795939)
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 258.23 Da
- Form: White crystalline powder
- Storage: -20°C
References
- Višnjić D, et al. Int J Mol Sci. 2021. PMID: 34064363
- AICAR diabetic neuropathy study. 2024. PMID: 39795939
SpecsCompound Specifications
Compound Specifications
- CAS Number
- 2627-69-2
- Molecular Formula
- C9H14N4O5
- Molecular Weight
- 258.23 Da
- Sequence
- C9H14N4O5
- PubChem CID
- 17513
- Form
- Lyophilized powder
- Storage
- −20°C or below, protected from light and moisture
HandlingStorage & Handling
Storage & Handling
Storage
AICAR is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
ResearchResearch Overview
Research Overview
AICAR is a synthetic peptide compound used in laboratory research settings. Researchers studying metabolic regulation and energy homeostasis use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. No third-party certificate is on file for this product yet.
Documentation & Resources
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What is AICAR?
AICAR is a research compound supplied for in-vitro laboratory use. Sequence: C9H14N4O5. Supplied for metabolic research laboratory research. Research Use Only — not for human or veterinary use.
What purity is AICAR?
No certificate with an HPLC purity figure is published for AICAR yet.
Does AICAR include a Certificate of Analysis?
No certificate is published for AICAR yet.
How should AICAR be stored?
AICAR is supplied as a lyophilized powder. Store it at −20°C or below, protected from light and moisture — lyophilized material is stable frozen. Once reconstituted, keep it refrigerated and avoid freeze-thaw cycles.
How is AICAR shipped?
Orders ship at a $15 flat rate, free on orders of $200 or more, in discreet, insulated packaging. Domestic delivery takes 2–3 business days — 2-day across California, nearby Nevada, and on orders of $250+.
Can AICAR be used on humans or animals?
No. AICAR is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
What is the CAS number for AICAR?
AICAR's CAS Registry Number is 2627-69-2, per PubChem (CID 17513).
What is the price per mg for AICAR?
The 10mg size of AICAR is $16.00 per mg. See the size selector above for per-mg pricing on every available size.
