Adipotide
PH-ADIP-001
Specifications
Description
Adipotide (CKGGRAKDC-GG-D(KLAKLAK)2) is a peptidomimetic that targets the vascular supply of white adipose tissue. This proapoptotic peptide selectively induces apoptosis in blood vessels feeding fat deposits.
Mechanism of Action
Adipotide contains a targeting sequence (CKGGRAKDC) that binds prohibitin on adipose vasculature, coupled to a proapoptotic domain that disrupts mitochondrial membranes. By destroying the blood supply to fat tissue, adipotide induces targeted apoptosis within blood vessels of white adipose tissue and results in rapid weight loss (Barnhart et al., 2011).
Research Applications
- Adipose tissue vascular targeting (Barnhart et al., 2011)
- Obesity research in primate models
- Proapoptotic peptide mechanisms
- Body composition studies
- Prohibitin receptor biology
Product Specifications
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: -20°C
References
- Barnhart KF, et al. "A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys." Sci Transl Med. 2011. PMID: 22072637
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
Adipotide is a synthetic peptide compound used in laboratory research settings. Researchers studying metabolic regulation and energy homeostasis use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for Adipotide — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
