5-Amino-1MQ
PH-5A1MQ-001
Specifications
Description
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor studied for its effects on cellular metabolism and energy regulation. This compound blocks the enzyme that converts NAD+ precursors into inactive metabolites.
Mechanism of Action
5-Amino-1MQ inhibits NNMT, an enzyme that methylates nicotinamide and depletes the NAD+ precursor pool. By blocking NNMT, the compound preserves cellular NAD+ levels and enhances energy expenditure in adipose tissue (Kraus et al., 2014).
Research Applications
- NAD+ metabolism and preservation (Kraus et al., 2014)
- NNMT enzyme inhibition studies
- Metabolic regulation research
- Cancer metabolism studies (Eckert et al., 2019)
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 173.21 Da
- Form: White crystalline powder
- Storage: Room temperature, protected from light
References
- Kraus D, et al. Nature. 2014. PMID: 24717514
- Eckert MA, et al. Nature. 2019. PMID: 31043742
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
5-Amino-1MQ is a synthetic peptide compound used in laboratory research settings. Researchers studying metabolic regulation and energy homeostasis use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for 5-Amino-1MQ — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
