B12
Catalog no. PH-B12Size 1000mcg/ml 10mlMW (reference) 1,344.4 Da
Description
B12 (methylcobalamin) is a research-grade compound with ≥99% purity, supplied in 10ml vials at 1000mcg/ml and 5000mcg/ml. It is used in laboratory studies of cellular energy metabolism, methylation pathways, and neurological function. This bioactive coenzyme form of vitamin B12 is directly utilized by cells without hepatic conversion.
Mechanism of Action
Methylcobalamin is one of two active coenzyme forms of vitamin B12, serving as the essential cofactor for methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), which converts homocysteine to methionine (Drennan et al., 1994).
Research Applications
- Methionine synthase cofactor structure and mechanism (PMID: 7712296)
- Peripheral neuropathy molecular pharmacology review (PMC11450300)
- Diabetic neuropathy supplementation research, 1-year oral RCT (PMID: 33513879)
References
- Drennan CL, et al. Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment. Curr Opin Struct Biol. 1994. PMID: 7712296
- Methylcobalamin as a candidate for chronic peripheral neuropathic pain therapy. PMC11450300
- Vitamin B12 Supplementation in Diabetic Neuropathy — 1-year oral trial (methylcobalamin 1000 mcg/day). PMID: 33513879
SpecsCompound Specifications
Compound Specifications
- Form
- Lyophilized powder
- Storage
- −20°C or below, protected from light and moisture
HandlingStorage & Handling
Storage & Handling
Storage
B12 is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
ResearchResearch Overview
Research Overview
B12 is a synthetic peptide compound used in laboratory research settings. Researchers studying metabolic regulation and energy homeostasis use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. No third-party certificate is on file for this product yet.
B12 compound facts
- CAS Number
- 13422-55-4
- Molecular Formula
- C63H91CoN13O14P
- Molecular Weight
- 1,344.4 Da
- PubChem CID
- 10898559
- Key PubMed references
- PMID 7712296, PMID 33513879
Documentation & Resources
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What is B12?
B12 is a research compound supplied for in-vitro laboratory use. Supplied for metabolic research laboratory research. Research Use Only — not for human or veterinary use.
What purity is B12?
No certificate with an HPLC purity figure is published for B12 yet.
Does B12 include a Certificate of Analysis?
No certificate is published for B12 yet.
How should B12 be stored?
B12 is supplied as a lyophilized powder. Store it at −20°C or below, protected from light and moisture — lyophilized material is stable frozen. Once reconstituted, keep it refrigerated and avoid freeze-thaw cycles.
How is B12 shipped?
Orders ship at a $15 flat rate, free on orders of $200 or more, in discreet, insulated packaging. Domestic delivery takes 2–3 business days — 2-day across California, nearby Nevada, and on orders of $250+.
Can B12 be used on humans or animals?
No. B12 is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
What is the CAS number for B12?
B12's CAS Registry Number is 13422-55-4, per PubChem (CID 10898559).
