ARA-290
PH-ARA290-001
Specifications
Description
ARA-290 (Cibinetide) is an 11-amino acid peptide derived from the tissue-protective domain of erythropoietin. This innate repair receptor agonist promotes tissue protection without erythropoietic effects.
Mechanism of Action
ARA-290 activates the innate repair receptor (IRR), a heteromer of erythropoietin receptor and CD131, triggering tissue-protective and anti-inflammatory signaling without affecting red blood cell production. Clinical studies show efficacy in small fiber neuropathy (Culver et al., 2017) and diabetic neuropathy (Brines et al., 2014).
Research Applications
- Small fiber neuropathy (Culver et al., 2017)
- Diabetic neuropathy research (Brines et al., 2014)
- Tissue repair mechanisms
- Anti-inflammatory pathways
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 1257.4 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Culver DA, et al. Respir Med. 2017. PMID: 24555851
- Brines M, et al. Mol Med. 2014. PMID: 25387363
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
ARA-290 is a synthetic peptide compound used in laboratory research settings. Researchers studying tissue repair and regeneration mechanisms use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for ARA-290 — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
