Melanotan I
PH-MT1-001
Specifications
Description
Melanotan I (Afamelanotide) is a linear analog of alpha-melanocyte stimulating hormone (α-MSH) with enhanced stability. This peptide selectively activates MC1R for pigmentation effects and is the only melanocortin approved for medical use.
Mechanism of Action
Melanotan I ([Nle4-D-Phe7]-α-MSH) binds primarily to MC1R melanocortin receptors on melanocytes, stimulating eumelanin production and skin pigmentation. The modifications confer resistance to enzymatic degradation and prolonged duration of action (Fabrikant et al., 2013). Clinical studies demonstrate its efficacy in mitigating photosensitivity in erythropoietic protoporphyria patients (Harms et al., 2009).
Research Applications
- Melanogenesis and pigmentation studies (Fabrikant et al., 2013)
- Photoprotection research (Harms et al., 2009)
- Erythropoietic protoporphyria treatment
- MC1R selective activation
- UV protection mechanisms
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 1646.9 Da
- Form: Lyophilized powder
- Storage: -20°C, protected from light
References
- Fabrikant J, et al. "A review and update on melanocyte stimulating hormone therapy: afamelanotide." J Drugs Dermatol. 2013. PMID: 23884489
- Harms J, et al. "Mitigating photosensitivity of erythropoietic protoporphyria patients by an agonistic analog of alpha-melanocyte stimulating hormone." Photochem Photobiol. 2009. PMID: 19656325
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
Melanotan I is a synthetic peptide compound used in laboratory research settings. Researchers studying melanocortin receptor system research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for Melanotan I — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
