FOXO4-DRI
PH-FOXO4-001
Specifications
Description
FOXO4-DRI is a cell-penetrating peptide designed to selectively induce apoptosis in senescent cells. This senolytic peptide disrupts the FOXO4-p53 interaction that maintains senescent cell viability.
Mechanism of Action
FOXO4-DRI is a D-retro-inverso peptide that interferes with the FOXO4-p53 axis in senescent cells. By disrupting this interaction, the peptide releases p53 to trigger apoptosis selectively in senescent cells while sparing healthy cells (Baar et al., 2017). Studies show efficacy in removing senescent chondrocytes (PMID: 33996787) and alleviating age-related testosterone decline (PMID: 31959736).
Research Applications
- Senescent cell clearance research (Baar et al., 2017)
- Chondrocyte senolysis (PMID: 33996787)
- Age-related hormone studies (PMID: 31959736)
- Tissue regeneration research
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: ~3000 Da
- Form: Lyophilized powder
- Storage: -20°C, protected from light
References
- Baar MP, et al. Cell. 2017. PMID: 28340339
- Chondrocyte senolysis study. 2021. PMID: 33996787
- Testosterone secretion study. 2020. PMID: 31959736
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
FOXO4-DRI is a synthetic peptide compound used in laboratory research settings. Researchers studying longevity and cellular aging research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for FOXO4-DRI — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
