Humanin
Catalog no. PH-HUM-001Size 10mgMW (reference) 2,687.2 DaSequence MAPRGFSCLLLLTSEIDLPVKRRA
Description
Humanin is a 24-amino acid mitochondrial-derived peptide encoded in the 16S ribosomal RNA region of mtDNA. This cytoprotective peptide was discovered through its ability to protect neurons from Alzheimer's disease-related toxicity.
Mechanism of Action
Humanin provides neuroprotection by counteracting apoptotic processes in neurons. Research demonstrates its role as a mitochondria-derived peptide that protects against Alzheimer's disease pathology (Cohen, 2021). Studies show molecular mechanisms of humanin's neuroprotective effects (PMID: 40090538).
Research Applications
- Alzheimer's disease research (Cohen, 2021)
- Neuroprotection mechanisms (PMID: 40090538)
- Mitochondrial-derived peptide signaling
- Cytoprotection and cell survival
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 2687.2 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Cohen P. Peptides. 2021. PMID: 34626746
- Neuroprotective mechanisms of Humanin. 2025. PMID: 40090538
SpecsCompound Specifications
Compound Specifications
- CAS Number
- 330936-69-1
- Molecular Formula
- C119H204N34O32S2
- Molecular Weight
- 2,687.2 Da
- Sequence
- MAPRGFSCLLLLTSEIDLPVKRRA
- PubChem CID
- 16131438
- Form
- Lyophilized powder
- Storage
- −20°C or below, protected from light and moisture
HandlingStorage & Handling
Storage & Handling
Storage
Humanin is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
ResearchResearch Overview
Research Overview
Humanin is a synthetic peptide compound used in laboratory research settings. Researchers studying longevity and cellular aging research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. No third-party certificate is on file for this product yet.
Documentation & Resources
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What is Humanin?
Humanin is a research compound supplied for in-vitro laboratory use. Sequence: MAPRGFSCLLLLTSEIDLPVKRRA. Supplied for longevity research laboratory research. Research Use Only — not for human or veterinary use.
What purity is Humanin?
No certificate with an HPLC purity figure is published for Humanin yet.
Does Humanin include a Certificate of Analysis?
No certificate is published for Humanin yet.
How should Humanin be stored?
Humanin is supplied as a lyophilized powder. Store it at −20°C or below, protected from light and moisture — lyophilized material is stable frozen. Once reconstituted, keep it refrigerated and avoid freeze-thaw cycles.
How is Humanin shipped?
Orders ship at a $15 flat rate, free on orders of $200 or more, in discreet, insulated packaging. Domestic delivery takes 2–3 business days — 2-day across California, nearby Nevada, and on orders of $250+.
Can Humanin be used on humans or animals?
No. Humanin is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
What is the CAS number for Humanin?
Humanin's CAS Registry Number is 330936-69-1, per PubChem (CID 16131438).
What is the price per mg for Humanin?
The 10mg size of Humanin is $27.50 per mg. See the size selector above for per-mg pricing on every available size.
