Humanin
PH-HUM-001
Specifications
Description
Humanin is a 24-amino acid mitochondrial-derived peptide encoded in the 16S ribosomal RNA region of mtDNA. This cytoprotective peptide was discovered through its ability to protect neurons from Alzheimer's disease-related toxicity.
Mechanism of Action
Humanin provides neuroprotection by counteracting apoptotic processes in neurons. Research demonstrates its role as a mitochondria-derived peptide that protects against Alzheimer's disease pathology (Cohen, 2021). Studies show molecular mechanisms of humanin's neuroprotective effects (PMID: 40090538).
Research Applications
- Alzheimer's disease research (Cohen, 2021)
- Neuroprotection mechanisms (PMID: 40090538)
- Mitochondrial-derived peptide signaling
- Cytoprotection and cell survival
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 2687.2 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Cohen P. Peptides. 2021. PMID: 34626746
- Neuroprotective mechanisms of Humanin. 2025. PMID: 40090538
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
Humanin is a synthetic peptide compound used in laboratory research settings. Researchers studying longevity and cellular aging research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for Humanin — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
