FOXO4-DRI
PH-FOXO4-001
Specifications
Description
FOXO4-DRI is a cell-penetrating peptide designed to selectively induce apoptosis in senescent cells. This senolytic peptide disrupts the FOXO4-p53 interaction that maintains senescent cell viability.
Mechanism of Action
FOXO4-DRI is a D-retro-inverso peptide that interferes with the FOXO4-p53 axis in senescent cells. By disrupting this interaction, the peptide releases p53 to trigger apoptosis selectively in senescent cells while sparing healthy cells (Baar et al., 2017). Studies show efficacy in removing senescent chondrocytes (PMID: 33996787) and alleviating age-related testosterone decline (PMID: 31959736).
Research Applications
- Senescent cell clearance research (Baar et al., 2017)
- Chondrocyte senolysis (PMID: 33996787)
- Age-related hormone studies (PMID: 31959736)
- Tissue regeneration research
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: ~3000 Da
- Form: Lyophilized powder
- Storage: -20°C, protected from light
References
- Baar MP, et al. Cell. 2017. PMID: 28340339
- Chondrocyte senolysis study. 2021. PMID: 33996787
- Testosterone secretion study. 2020. PMID: 31959736
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
FOXO4-DRI is a synthetic peptide compound used in laboratory research settings. Researchers studying longevity and cellular aging research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is FOXO4-DRI?
Each lot of FOXO4-DRI is verified to ≥99% by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does FOXO4-DRI include a Certificate of Analysis?
Yes. Every order includes batch-specific analytical documentation — a Certificate of Analysis covering purity and identity.
How should FOXO4-DRI be stored?
FOXO4-DRI is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is FOXO4-DRI shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can FOXO4-DRI be used on humans or animals?
No. FOXO4-DRI is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
