MOTS-c

MOTS-c is a groundbreaking 16-amino acid mitochondrial-derived peptide (sequence: MRWQEMGYIFYPRKLR) encoded within mitochondrial DNA. This signaling peptide acts as a critical messenger between mitochondria and nucleus, orchestrating adaptive responses to metabolic stress.

Mechanism of Action

MOTS-c regulates the folate-methionine cycle and activates AMP-activated protein kinase (AMPK), a central cellular energy sensor. Under metabolic challenge, MOTS-c translocates to the nucleus and interacts with the antioxidant response element (ARE), upregulating stress resistance genes. MOTS-c is an exercise-induced mitochondrial-encoded regulator that significantly enhances physical performance across different age groups and can regulate both nuclear genes and skeletal muscle metabolism (Reynolds et al., 2021). The peptide promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee et al., 2015).

Research Applications

• Metabolic regulation and insulin sensitivity studies (Lee et al., 2015)
• Exercise mimetic research and energy metabolism (Reynolds et al., 2021)
• Obesity and metabolic syndrome models
• Longevity and healthspan extension research
• Muscle homeostasis and sarcopenia

Product Specifications

• Purity: 99.789% (HPLC verified)
• Molecular Weight: 2174.6 Da
• Sequence: MRWQEMGYIFYPRKLR
• Form: Lyophilized powder
• Storage: -20°C, protected from light

References

1. Reynolds JC, et al. "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis." Nat Commun. 2021. PMID: 33473109
2. Lee C, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." Cell Metab. 2015. PMID: 25738459