MOTS-c is a groundbreaking 16-amino acid mitochondrial-derived peptide (sequence: MRWQEMGYIFYPRKLR) encoded within mitochondrial DNA. Our current lot, 98774, tested 99.983% HPLC purity with identity confirmed by Accumark Labs (report HDHR-QA5T, completed Sep 28, 2026)
Lot 98774
Tested on the 22.009 mg vial
Sample received Sep 24, 2026 · Analysis completed Sep 28, 2026
Conforms spec > 98.0%
Conforms
Measured
Figures copied exactly from Accumark Labs's report HDHR-QA5T.
Catalog no. PH-MOTSC-001Size 10mgMW (reference) 2,174.6 DaSequence MRWQEMGYIFYPRKLR
MOTS-c is a groundbreaking 16-amino acid mitochondrial-derived peptide (sequence: MRWQEMGYIFYPRKLR) encoded within mitochondrial DNA. This signaling peptide acts as a critical messenger between mitochondria and nucleus, orchestrating adaptive responses to metabolic stress.
Mechanism of Action
MOTS-c regulates the folate-methionine cycle and activates AMP-activated protein kinase (AMPK), a central cellular energy sensor. Under metabolic challenge, MOTS-c translocates to the nucleus and interacts with the antioxidant response element (ARE), upregulating stress resistance genes. MOTS-c is an exercise-induced mitochondrial-encoded regulator that significantly enhances physical performance across different age groups and can regulate both nuclear genes and skeletal muscle metabolism (Reynolds et al., 2021). The peptide promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee et al., 2015).
Research Applications
Product Specifications
References
MOTS-c is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
MOTS-c is a synthetic peptide compound used in laboratory research settings. Researchers studying longevity and cellular aging research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Its available Certificate of Analysis documents the reported laboratory results.
MOTS-c is a research compound supplied for in-vitro laboratory use. Also known as MOTSc, MOTS c. Sequence: MRWQEMGYIFYPRKLR. Supplied for longevity research laboratory research. A third-party Certificate of Analysis is published for the current lot. Research Use Only — not for human or veterinary use.
The current Certificate of Analysis for MOTS-c reports 99.983% purity by HPLC (Accumark Labs report HDHR-QA5T).
Yes. Accumark Labs report HDHR-QA5T for MOTS-c is on our COA page, with a link to the lab's own report.
MOTS-c is supplied as a lyophilized powder. Store it at −20°C or below, protected from light and moisture — lyophilized material is stable frozen. Once reconstituted, keep it refrigerated and avoid freeze-thaw cycles.
Orders ship at a $15 flat rate, free on orders of $200 or more, in discreet, insulated packaging. Domestic delivery takes 2–3 business days — 2-day across California, nearby Nevada, and on orders of $250+.
No. MOTS-c is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
Yes. MOTS-c is also spelled or referred to as MOTSc, MOTS c. These are naming variants of the same compound, not different products.
MOTS-c's CAS Registry Number is 1627580-64-6, per PubChem (CID 146675088).
Open the lab report link on our certificate page — it goes to Accumark Labs's own verification portal, not a file we host, so the result can't be edited by us. Confirm the report ID (HDHR-QA5T) and figures match what's shown here.
The 10mg size of MOTS-c is $6.00 per mg. See the size selector above for per-mg pricing on every available size.
