Kisspeptin
PH-KISS-001
Specifications
Description
Kisspeptin is a family of neuropeptides encoded by the KISS1 gene that serve as critical regulators of reproductive function. These peptides activate the kisspeptin receptor (GPR54/KISS1R) to control gonadotropin-releasing hormone (GnRH) secretion.
Mechanism of Action
Kisspeptin directly stimulates GnRH neurons in the hypothalamus, triggering the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The kisspeptin system is essential for puberty onset and reproductive function, serving as a pivotal factor in the pubertal activation of the reproductive cascade (Kaiser & Kuohung, 2005). Kisspeptin expression in the brain acts as a catalyst for the initiation of puberty (Smith et al., 2007).
Research Applications
- Reproductive endocrinology (Kaiser & Kuohung, 2005)
- Puberty and fertility research (Smith et al., 2007)
- GnRH regulation studies
- Hypogonadism research
- HPG axis modulation
Product Specifications
- Purity: ≥99% (HPLC verified)
- Forms available: Kisspeptin-10, Kisspeptin-54
- Form: Lyophilized powder
- Storage: -20°C
References
- Kaiser UB, Kuohung W. "KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty." Endocrinology. 2005. PMID: 16034182
- Smith JT, et al. "Kisspeptin expression in the brain: catalyst for the initiation of puberty." Trends Endocrinol Metab. 2007. PMID: 17334929
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
Kisspeptin is a synthetic peptide compound used in laboratory research settings. Researchers studying cognitive function and neuroprotection use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for Kisspeptin — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
