Dihexa
PH-DIHEX-001
Specifications
Description
Dihexa is a small molecule angiotensin IV analog with potent procognitive effects. This orally active compound crosses the blood-brain barrier and acts as an HGF/c-Met system agonist.
Mechanism of Action
Dihexa binds hepatocyte growth factor (HGF) with high affinity and enhances c-Met receptor activation, promoting synaptogenesis and spinogenesis in hippocampal neurons. A systematic review demonstrates consistent cognitive benefits of angiotensin IV analogs including Dihexa in memory and learning tasks (Royea & Bherer, 2018). Research explores therapeutic applications for Alzheimer's and Parkinson's diseases (Wright et al., 2015).
Research Applications
- Cognitive enhancement studies (Royea & Bherer, 2018)
- HGF/c-Met signaling research (Wright et al., 2015)
- Synaptic plasticity and memory formation
- Neurodegenerative disease models
- Neuronal growth factor research
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 323.4 Da
- Form: Lyophilized powder
- Storage: -20°C, protected from light
References
- Royea J & Bherer L. J Renin Angiotensin Aldosterone Syst. 2018. PMID: 29733881
- Wright JW, et al. Pharmacol Ther. 2015. PMID: 25455861
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
Dihexa is a synthetic peptide compound used in laboratory research settings. Researchers studying cognitive function and neuroprotection use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for Dihexa — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is Dihexa?
Each lot of Dihexa is verified to ≥99% by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does Dihexa include a Certificate of Analysis?
Yes. A batch-specific Certificate of Analysis for Dihexa documents its purity and identity and is available on our COA page.
How should Dihexa be stored?
Dihexa is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is Dihexa shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can Dihexa be used on humans or animals?
No. Dihexa is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
