PE-22-28
Catalog no. PH-PE2228-001Size 10mgMW (reference) 773.9 DaSequence Spadin analog
Description
PE-22-28 is a heptapeptide derived from the spadin sequence, identified as a potent TREK-1 potassium channel blocker with antidepressant properties.
Mechanism of Action
PE-22-28 inhibits TREK-1 (TWIK-related potassium channel 1), a two-pore domain potassium channel involved in neuronal excitability and mood regulation. By blocking TREK-1, this peptide enhances neuronal firing and mediates antidepressant-like effects in preclinical models. PE-22-28 displays better specificity and affinity for TREK-1 channel compared to spadin, with significantly improved in vivo stability and antidepressant activity (Djillani et al., 2017). Spadin, from which PE-22-28 is derived, was identified as the first natural antidepressant peptide that specifically blocks TREK-1 channels (Mazella et al., 2010).
Research Applications
- TREK-1 channel pharmacology and drug discovery (Djillani et al., 2017)
- Novel antidepressant mechanism studies (Mazella et al., 2010)
- Two-pore domain potassium channel research
- Mood disorder and anxiety models
- Neuropsychiatric target validation
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 773.9 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Djillani A, et al. "Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity." Front Pharmacol. 2017. PMID: 28955242
- Mazella J, et al. "Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design." PLoS Biol. 2010. PMID: 20405001
SpecsCompound Specifications
Compound Specifications
- Also known as
- PE 22-28
- Form
- Lyophilized powder
- Storage
- −20°C or below, protected from light and moisture
HandlingStorage & Handling
Storage & Handling
Storage
PE-22-28 is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
ResearchResearch Overview
Research Overview
PE-22-28 is a synthetic peptide compound used in laboratory research settings. Researchers studying neuropeptide signaling and receptor research use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. No third-party certificate is on file for this product yet.
PE-22-28 compound facts
- CAS Number
- 1801959-12-5
- Molecular Formula
- C35H55N11O9
- Molecular Weight
- 773.9 Da
- Sequence
- Spadin analog
- PubChem CID
- 165437303
- Key PubMed references
- PMID 28955242, PMID 20405001
Research articles on PE-22-28
Documentation & Resources
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What is PE-22-28?
PE-22-28 is a research compound supplied for in-vitro laboratory use. Also known as PE 22-28. Sequence: Spadin analog. Supplied for neuropeptides laboratory research. Research Use Only — not for human or veterinary use.
What purity is PE-22-28?
No certificate with an HPLC purity figure is published for PE-22-28 yet.
Does PE-22-28 include a Certificate of Analysis?
No certificate is published for PE-22-28 yet.
How should PE-22-28 be stored?
PE-22-28 is supplied as a lyophilized powder. Store it at −20°C or below, protected from light and moisture — lyophilized material is stable frozen. Once reconstituted, keep it refrigerated and avoid freeze-thaw cycles.
How is PE-22-28 shipped?
Orders ship at a $15 flat rate, free on orders of $200 or more, in discreet, insulated packaging. Domestic delivery takes 2–3 business days — 2-day across California, nearby Nevada, and on orders of $250+.
Can PE-22-28 be used on humans or animals?
No. PE-22-28 is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
Is PE-22-28 the same as PE 22-28?
Yes. PE-22-28 is also spelled or referred to as PE 22-28. These are naming variants of the same compound, not different products.
What is the CAS number for PE-22-28?
PE-22-28's CAS Registry Number is 1801959-12-5, per PubChem (CID 165437303).
What is the price per mg for PE-22-28?
The 10mg size of PE-22-28 is $6.60 per mg. See the size selector above for per-mg pricing on every available size.
