PE-22-28
PH-PE2228-001
Specifications
- Size
- 10mg
- Molecular Weight
- 758.9 Da
- Catalog No.
- PH-PE2228-001
Description
PE-22-28 is a heptapeptide derived from the spadin sequence, identified as a potent TREK-1 potassium channel blocker with antidepressant properties.
Mechanism of Action
PE-22-28 inhibits TREK-1 (TWIK-related potassium channel 1), a two-pore domain potassium channel involved in neuronal excitability and mood regulation. By blocking TREK-1, this peptide enhances neuronal firing and mediates antidepressant-like effects in preclinical models. PE-22-28 displays better specificity and affinity for TREK-1 channel compared to spadin, with significantly improved in vivo stability and antidepressant activity (Djillani et al., 2017). Spadin, from which PE-22-28 is derived, was identified as the first natural antidepressant peptide that specifically blocks TREK-1 channels (Mazella et al., 2010).
Research Applications
- TREK-1 channel pharmacology and drug discovery (Djillani et al., 2017)
- Novel antidepressant mechanism studies (Mazella et al., 2010)
- Two-pore domain potassium channel research
- Mood disorder and anxiety models
- Neuropsychiatric target validation
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: ~800 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Djillani A, et al. "Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity." Front Pharmacol. 2017. PMID: 28955242
- Mazella J, et al. "Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design." PLoS Biol. 2010. PMID: 20405001
Verification
Storage & Handling
Storage
PE-22-28 is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Reconstitution
Let the vial reach room temperature before opening, then add solvent slowly down the vial wall — do not shake.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
Research Overview
PE-22-28 is a synthetic peptide compound used in laboratory research settings. Researchers studying cognitive function and neuroprotection use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for PE-22-28 — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is PE-22-28?
Each lot of PE-22-28 is verified by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does PE-22-28 include a Certificate of Analysis?
Yes. A batch-specific Certificate of Analysis for PE-22-28 documents its purity and identity and is available on our COA page.
How should PE-22-28 be stored?
PE-22-28 is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is PE-22-28 shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can PE-22-28 be used on humans or animals?
No. PE-22-28 is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
