ACE-031
PH-ACE031-001
Specifications
Description
ACE-031 is a soluble ActRIIB-Fc fusion protein that acts as a myostatin and activin decoy receptor. This research compound inhibits TGF-β superfamily signaling to promote muscle growth.
Mechanism of Action
ACE-031 binds circulating myostatin and activins, preventing their interaction with cell-surface receptors. Clinical studies showed increases in lean body mass and bone mineral density (Campbell et al., 2017). Single ascending dose studies demonstrated pharmacodynamic activity in healthy volunteers (Attie et al., 2013).
Research Applications
- Myostatin inhibition studies (Campbell et al., 2017)
- Muscle biology research (Attie et al., 2013)
- TGF-β superfamily signaling
- Muscle wasting conditions
- Body composition research
Product Specifications
- Purity: ≥95% (SDS-PAGE verified)
- Molecular Weight: ~110 kDa
- Form: Lyophilized powder
- Storage: -20°C
References
- Campbell C, et al. Neuromuscul Disord. 2017. PMID: 27462804
- Attie KM, et al. Clin Pharmacol Drug Dev. 2013. PMID: 23169607
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
ACE-031 is a synthetic peptide compound used in laboratory research settings. Researchers studying growth hormone releasing hormone pathways use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for ACE-031 — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
