IGF-1 DES
Catalog no. PH-IGFDES-001Size 10mgMW (reference) 7365.4 DaMechanism Truncated IGF-1 (67 amino acids)
Description
IGF-1 DES (Des(1-3)IGF-1) is a truncated form of insulin-like growth factor 1 lacking the first three N-terminal amino acids (Gly-Pro-Glu). This modification eliminates binding to IGF binding proteins, enhancing bioactivity.
Mechanism of Action
Des(1-3)IGF-1 demonstrates approximately 10-fold greater potency than standard IGF-I in stimulating cellular growth due to reduced sequestration by IGF binding proteins (Ballard et al., 1996). The truncation maintains receptor binding while increasing free hormone availability, making it significantly more potent in promoting proliferation (Francis et al., 1992).
Research Applications
- Enhanced IGF-1 activity studies (Ballard et al., 1996)
- IGFBP-independent signaling (Francis et al., 1992)
- Cell proliferation research
- Tissue regeneration
- Localized growth factor effects
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 7365 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Ballard FJ, et al. "Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I." Horm Res. 1996. PMID: 8930132
- Francis GL, et al. "Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency." J Mol Endocrinol. 1992. PMID: 1378742
SpecsCompound Specifications
Compound Specifications
- Also known as
- IGF1 DES
- Molecular Weight
- 7365.4 Da
- Mechanism
- Truncated IGF-1 (67 amino acids)
- Form
- Lyophilized powder
- Storage
- −20°C or below, protected from light and moisture
HandlingStorage & Handling
Storage & Handling
Storage
IGF-1 DES is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
ResearchResearch Overview
Research Overview
IGF-1 DES is a synthetic peptide compound used in laboratory research settings. Researchers studying growth hormone releasing hormone pathways use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. No third-party certificate is on file for this product yet.
Documentation & Resources
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What is IGF-1 DES?
IGF-1 DES is a research compound supplied for in-vitro laboratory use. Also known as IGF1 DES. Mechanism class: Truncated IGF-1 (67 amino acids). Supplied for growth hormone releasing laboratory research. Research Use Only — not for human or veterinary use.
What purity is IGF-1 DES?
No certificate with an HPLC purity figure is published for IGF-1 DES yet.
Does IGF-1 DES include a Certificate of Analysis?
No certificate is published for IGF-1 DES yet.
How should IGF-1 DES be stored?
IGF-1 DES is supplied as a lyophilized powder. Store it at −20°C or below, protected from light and moisture — lyophilized material is stable frozen. Once reconstituted, keep it refrigerated and avoid freeze-thaw cycles.
How is IGF-1 DES shipped?
Orders ship at a $15 flat rate, free on orders of $200 or more, in discreet, insulated packaging. Domestic delivery takes 2–3 business days — 2-day across California, nearby Nevada, and on orders of $250+.
Can IGF-1 DES be used on humans or animals?
No. IGF-1 DES is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
Is IGF-1 DES the same as IGF1 DES?
Yes. IGF-1 DES is also spelled or referred to as IGF1 DES. These are naming variants of the same compound, not different products.
What is the price per mg for IGF-1 DES?
The 10mg size of IGF-1 DES is $25.80 per mg. See the size selector above for per-mg pricing on every available size.
