IGF-1 DES
PH-IGFDES-001
Specifications
Description
IGF-1 DES (Des(1-3)IGF-1) is a truncated form of insulin-like growth factor 1 lacking the first three N-terminal amino acids (Gly-Pro-Glu). This modification eliminates binding to IGF binding proteins, enhancing bioactivity.
Mechanism of Action
Des(1-3)IGF-1 demonstrates approximately 10-fold greater potency than standard IGF-I in stimulating cellular growth due to reduced sequestration by IGF binding proteins (Ballard et al., 1996). The truncation maintains receptor binding while increasing free hormone availability, making it significantly more potent in promoting proliferation (Francis et al., 1992).
Research Applications
- Enhanced IGF-1 activity studies (Ballard et al., 1996)
- IGFBP-independent signaling (Francis et al., 1992)
- Cell proliferation research
- Tissue regeneration
- Localized growth factor effects
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 7365 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Ballard FJ, et al. "Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I." Horm Res. 1996. PMID: 8930132
- Francis GL, et al. "Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency." J Mol Endocrinol. 1992. PMID: 1378742
Documentation
Storage and Handling
- ❄️ Store lyophilized peptide at -20°C or below
- 🔒 Protect from light and moisture
- 🌡️ Allow vial to reach room temperature before opening
- 💧 Reconstitute with appropriate sterile solvent
- 📦 Aliquot to avoid repeated freeze-thaw cycles
Research Overview
IGF-1 DES is a synthetic peptide compound used in laboratory research settings. Researchers studying growth hormone releasing hormone pathways use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for IGF-1 DES — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
