IGF-1 DES
PH-IGFDES-001
Specifications
- Purity (HPLC)
- ≥99%
- Size
- 10mg
- Molecular Weight
- 7365.4 Da
- Catalog No.
- PH-IGFDES-001
Description
IGF-1 DES (Des(1-3)IGF-1) is a truncated form of insulin-like growth factor 1 lacking the first three N-terminal amino acids (Gly-Pro-Glu). This modification eliminates binding to IGF binding proteins, enhancing bioactivity.
Mechanism of Action
Des(1-3)IGF-1 demonstrates approximately 10-fold greater potency than standard IGF-I in stimulating cellular growth due to reduced sequestration by IGF binding proteins (Ballard et al., 1996). The truncation maintains receptor binding while increasing free hormone availability, making it significantly more potent in promoting proliferation (Francis et al., 1992).
Research Applications
- Enhanced IGF-1 activity studies (Ballard et al., 1996)
- IGFBP-independent signaling (Francis et al., 1992)
- Cell proliferation research
- Tissue regeneration
- Localized growth factor effects
Product Specifications
- Purity: ≥99% (HPLC verified)
- Molecular Weight: 7365 Da
- Form: Lyophilized powder
- Storage: -20°C
References
- Ballard FJ, et al. "Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I." Horm Res. 1996. PMID: 8930132
- Francis GL, et al. "Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency." J Mol Endocrinol. 1992. PMID: 1378742
Verification
Storage & Handling
Storage
IGF-1 DES is supplied as a lyophilized powder. Keep it sealed, dry, and away from light until reconstitution.
Reconstitution
Let the vial reach room temperature before opening, then add solvent slowly down the vial wall — do not shake.
Stability
Lyophilized material is stable when frozen. Once reconstituted, keep it cold and minimise handling to preserve integrity.
Research Overview
IGF-1 DES is a synthetic peptide compound used in laboratory research settings. Researchers studying growth hormone releasing hormone pathways use this compound to investigate cellular signaling pathways, receptor binding affinities, and structure-activity relationships. Each batch is manufactured under controlled conditions and verified through HPLC and mass spectrometry analysis to ensure consistency across experimental replicates.
Documentation & Resources
- Certificate of Analysis for IGF-1 DES — batch-specific purity and identity verification
- Research Blog — protocols, guides, and peptide research literature
- Research Use Policy — handling and compliance guidelines
Frequently Asked Questions
What purity is IGF-1 DES?
Each lot of IGF-1 DES is verified to ≥99% by HPLC and confirmed by mass spectrometry. Results are documented in a batch-specific Certificate of Analysis.
Does IGF-1 DES include a Certificate of Analysis?
Yes. A batch-specific Certificate of Analysis for IGF-1 DES documents its purity and identity and is available on our COA page.
How should IGF-1 DES be stored?
IGF-1 DES is supplied as a lyophilized powder. For short-term storage keep it refrigerated; for long-term storage keep it frozen, away from light and moisture.
How is IGF-1 DES shipped?
Orders ship at a $15 flat rate, free on orders over $199, in discreet, insulated packaging. Domestic delivery typically takes 1–3 business days.
Can IGF-1 DES be used on humans or animals?
No. IGF-1 DES is supplied strictly for in-vitro laboratory research. It is not for human or veterinary use, consumption, or diagnostic or clinical applications.
